LYMPHOID NEOPLASIA Brief report Prognosis of Binet stage A chronic lymphocytic leukemia patients: the strength of routine parameters
نویسندگان
چکیده
1Université Paris13, Unité de Formation et de Recherche Santé-Médecine-Biologie Humaine (UFR SMBH), Bobigny, France; 2Unité Mixte de Recherche (UMR) U978, Inserm, UFR SMBH, Bobigny, France; 3Service d’Hématologie Biologique, Hôpital Avicenne, Assistance Publique–Hôpitaux de Paris (AP-HP), Bobigny, France; 4Pôle Hématologie Oncologie, Hôpital Avicenne, AP-HP, Bobigny, France; 5Inserm U717, Hôpital Saint Louis, Paris, France; 6Laboratoire d’Hématologie, Centre Hospitalier de l’Université (CHU) Côte de Nacre, Caen, France; 7Service de biochimie, Hôpital Avicenne, AP-HP, Bobigny, France; and 8Service d’Hématologie Biologique, Hôpital Pitié Salpétrière, AP-HP, Paris, France
منابع مشابه
Prognosis of Binet stage A chronic lymphocytic leukemia patients: the strength of routine parameters.
Recent developments in the management of chronic lymphocytic leukemia (CLL) patients have made necessary the availability of dependable prognostic factors. We have developed a prognostic index derived from the multivariate analysis of 339 stage A patients at diagnosis, exhaustively studied for classical and recent predictive markers. Only 4 biologic parameters were found to be independent predi...
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Chronic lymphocytic leukemia (CLL) is a malignancy of B CD5+cells and is the most common type of leukemia in adults. The disease is more common in men over 50 years in western countries. CLL is associated with defective apoptosis in B cells. CLL was traditionally regarded as a disease that occurs before naïve B cells meet the antigen in the lymph nodes. Laboratory diagnosis requires white blood...
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We determined lymphoid enhancer-binding factor-1 (LEF1) mRNA expression in 112 chronic lymphocytic leukemia (CLL) samples and assessed correlations with the prognostic markers ZAP70 and CD38, Binet stages, the percentage of lymphocytes in the peripheral blood, and fibromodulin (FMOD) transcripts. The mean LEF1 relative expression ratios (RER) were 53.72 and 37.10 in ZAP70-positive and ZAP70-neg...
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BACKGROUND The expression levels of LPL, ZAP70, TCL1A, CLLU1 and MCL1 have recently been proposed as prognostic factors in chronic lymphocytic leukemia. However, few studies have systematically compared these different RNA-based markers. DESIGN AND METHODS Using real-time quantitative PCR, we measured the mRNA expression levels of these genes in unsorted samples from 252 newly diagnosed chron...
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Identification of prognosticators for Binet A chronic lymphocytic leukemia is important for selecting patients with dismal prognosis. We analyzed CD49d expression in 140 consecutive Binet A chronic lymphocytic leukemia. At diagnosis, CD49d >or=30% (54/140, 38.6%) associated with proliferation markers, namely CD38 >or=30% (p=3.9 x 10(-6)), LDH (p=0.007) and beta2-microglobulin (p=0.020). Univari...
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